If you experience any of the following serious side effects, stop taking pioglitazone and seek emergency medical attention or notify your doctor immediately:
* an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
* nausea, vomiting, abdominal pain, or loss of appetite;
* unusual fatigue;
* yellowing of the skin or eyes; or
* Dark urine.
Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (swelling, water retention), shortness of breath, or chest pain during treatment with pioglitazone. These may be early symptoms of heart problems.
Other less serious side effects may also occur. Continue to take pioglitazone and talk to your doctor if you experience:
* headache;
* muscle aches; or
* Sore throat, nasal discharge, or cold symptoms.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Keep all appointments with your doctor.
Do not let anyone else take your medicines.
